 In contrast with autism, copy number increase of DUF1220 subtypes CON1 and HLS1 is associated with reduced severity of positive symptoms in schizophrenia.As a result of the direct correlation between brain size and schizophrenia, along with the correlations between brain size and the DUF1220 protein domain, it can be assumed that there is also a correlation between schizophrenia and the DUF1220 protein domain.The dosage of the Olduvai protein domain increases along with brain size, which is seen through the evolution from primates to humans.