 DCC and neogenin, two of the netrin-1 receptors, have recently been shown to have sites for tyrosine phosphorylation (at Y1420 on DCC) and are likely interacting with Src family kinases in regulating responses to netrin-1.Historically, cellular receptors have been thought to be activated when bound to their ligand, and are relatively inactive when no ligand is present.A number of receptors have been found that do not fit into this conceptual mould, and DCC is one of them.