 Conversely, when Olduvai copy number is increased, neurons appear to mature for longer and divide in higher numbers.DUF1220 copy number variation have recently been investigated in autism which is a disorder associated with deletions and duplications of 1q21 yet the causative loci within such regions have not previously been identified.Such research has found that copy number of DUF1220 subtype CON1 is linearly associated with increasing severity of social impairment in autism.