 His teacher and the founder of psychoanalysis, Sigmund Freud, explored the role of body in neurosis, as well as undertaking research on the therapeutic effects of cocaine (beginning on April 24, 1884, when he ordered his first gram of cocaine from the local apothecary).Freud also showed an interest in the nasal reflex neurosis and in vital periodicity, explored during a significant relationship with Wilhelm Fliess between 1887 and 1902.Wilhelm Fliess believed that the nose was the centre of all human illness through its structural deviations to the passage of breath.