 In 335 BCE, Alexander the Great's general Parmenion laid siege to the city as part of a campaign against the Persian Empire, but the city was saved by the Persian general Memnon of Rhodes.In c. 319 BCE its citizen Herakleitos son of Lysistratos was honoured by the people of Delphi, and in the period c. 325 - c. 275 BCE the people of Abydos honoured another citizen, Charidemos son of Antiphanes with a dedication at Delphi which included a statue by the famous Athenian sculptor Praxiteles.In the reign of the Seleucid king Antiochus I Soter (r. 281-261 BCE), Pitane was able to expand its territory by paying the king 380 talents to purchase some territory.