 Upon joining Spartak Moscow, De Zeeuw would play in the same position, just like he did at Ajax, Valeri Karpin suggested.After being absent for two games at the start of the season, De Zeeuw made his debut for the club in a 4–2 win over Terek Grozny on 7 August 2011.After a slow start, De Zeeuw scored his first goal for the club in a 3–0 win over Krylia Sovetov Samara on 18 September 2011.