 In the late 1920s, his first strips, "Vanilla and the Villains" and "Hard Hearted Hickey", appeared, followed by "Donnie".In 1930, he took over "Little Annie Rooney" (except for Sundays) from two previous artists for the "New York Journal".During the height of "Little Annie Rooney"'s popularity, McClure built a house in Greenwich, Connecticut, home to many famous cartoonists, and he lived and worked there from 1939 to 1947.