 Researchers in Canada and the UK found that despite the large increase, the percentage of mutation carriers remained the same, meaning Jolie's message had reached those most at risk.In her first op-ed, Jolie had advocated wider accessibility of BRCA gene testing and acknowledged the high costs, which were greatly reduced after the U.S. Supreme Court, in a June 2013 ruling, invalidated BRCA gene patents held by Myriad Genetics.As the daughter of actor Jon Voight, Jolie appeared in the media from an early age.