 In 2001 Twinlab sold ARP to Steve Blechman who then resigned from Twinlab.After slumping sales in 2002, the company filed a voluntary petition for Chapter 11 reorganization with the U.S. Bankruptcy Court for the Southern District of New York in September 2003.In 2004, Twinlab Corp., Twin Laboratories Inc. and Twin Laboratories (UK) Ltd. were purchased for $65 million by IdeaSphere Inc.

Ideasphere also known as ISI brands, and which also operated as Twinlab, went on to acquire other dietary supplement brands such as Metabolife, Nature's Herbs, Alvita Teas, and a publisher, Rebus LLC.