 Additional studies have shown that this activated version of MR can positively respond to ligands that are traditionally antagonists, such as endogenous hormones like progesterone, and the diuretic drugs spironolactone and eplerenone.Currently, the non-steroidal anti-mineralocorticoid drug Finerenone (Bayer) is in phase III clinical trials for the treatment of chronic heart failure.Mineralocorticoid receptor has been shown to interact with