 Mouse prickle-2 was found to be expressed in mature neurons of the brain along with mouse homologs of "Drosophila" planar polarity genes flamingo and dischevelled.Prickle interacts with flamingo to regulate sensory axon advance at the transition between the peripheral nervous system and the central nervous system.Also, Prickle1 interacts with RE1-silencing transcription factor (REST) by transporting REST out of the nucleus.