 By comparison the Glaser coupling would simply produce a distribution of all possible couplings.In one study the Cadiot–Chodkiewicz coupling has been applied in the synthesis of acetylene macrocycles starting from "cis"-1,4-diethynyl-1,4-dimethoxycyclohexa-2,5-diene.This compound is also the starting material for the dibromide through "N"-bromosuccinimide (NBS) and silver nitrate