 In a guinea pig model of aortic stenosis and left ventricular hypertrophy, beta-catenin was shown to change subcellular localization from intercalated discs to the cytosol, despite no change in the overall cellular abundance of beta-catenin.vinculin showed a similar profile of change.N-cadherin showed no change, and there was no compensatory upregulation of plakoglobin at intercalated discs in the absence of beta-catenin.