 It has been shown that beta-catenin forms a complex with emerin in cardiomyocytes at adherens junctions within intercalated discs; and this interaction is dependent on the presence of GSK 3-beta phosphorylation sites on beta-catenin.Knocking out emerin significantly altered beta-catenin localization and the overall intercalated disc architecture, which resembled a dilated cardiomyopathy phenotype.In animal models of cardiac disease, functions of beta-catenin have been unveiled.