 In 1916, he married Chicago-born Katherine Lupo Cardinale whose parents had emigrated from Sicily.Her brother was the boxer Charles Kid Lucca, Canadian champion welter-weight champion from 1910-1914.They had three more sons, Sebastian de Grazia, winner of the Pulitzer Prize, Edward de Grazia, a prominent first amendment lawyer and co-founder of Cardozo School of Law at Yeshiva University, and Victor de Grazia who was Deputy-Governor of the State of Illinois from 1973 to 1977.