 A makeshift Spanish army consisting mostly of Castilian troops defeated the Navarrese and French forces sent by Henry d'Albret and commanded by Lesparre, driving them out of Iberian Navarre.The Siege of Mézières (1521) took place during the Italian War of 1521–26.An Imperial army besieged the city (now part of Charleville-Mézières), which was defended by French troops under the command of the Chevalier de Bayard and Anne de Montmorency; the siege was unsuccessful, and the determined French resistance gave Francis I time to concentrate his forces against Charles V.

The Siege of Tournai (1521) took place during the Italian War of 1521–26.