 The marriage was announced in Great Britain 10 January 1765.The same year, 1764, she received a proposal from her brother's brother-in-law, Adolf Frederick of Mecklenburg-Strelitz, but negotiations were again deterred due to concerns regarding her health.Reportedly, by the time her sister Caroline Matilda left Great Britain for Denmark in 1766, Louisa was succumbing to a more and more deteriorating state of health due to an advancing tuberculosis, which eventually turned her into an invalid.