 Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer.Alterations in the localization and expression levels of beta-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy.β-catenin is regulated and destroyed by the "beta-catenin destruction complex", and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene.