 Prior to joining the Kingdom of Italy, Città Sant'Angelo was the capital city from 1837 to 1848 in the Distretto di Città Sant'Angelo, an administrative unit of Abruzzo Ulteriore Primo (the future Province of Teramo), a province of the Kingdom of the Two Sicilies, then returned to Penne County when the capital was returned to Penne.At the turn of the 20th century, many people left the region and joined the mass migration to the Americas.During the Second World War in April 1940 the Ministry of the Interior set up and rented the building of the Ex Manifattura Tabacchi, in the historic center of the city, to serve it as the only concentration camp of the province of Pescara with about 200 prisoners from Yugoslavia.