 Intercalated disc architecture was severely impaired and connexin 43-resident gap junctions were markedly reduced.Electrocardiogram measurements captured spontaneous lethal ventricular arrhythmias in the double transgenic animals, suggesting that the two catenins—beta-catenin and plakoglobin are critical and idispensible for mechanoelectrical coupling in cardiomyocytes.Whether or not a given individual's brain can deal effectively with stress, and thus their susceptibility to depression, depends on the beta-catenin in each person's brain, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published November 12, 2014 in the journal Nature.