 It is a member of the cytokine receptor family.EpoR pre-exists as dimers
 which upon binding of a 30 kDa ligand erythropoietin (Epo), changes its homodimerized state.These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e., EpoR does not possess intrinsic kinase activity and depends on Jak2 activity).