 De los Santos won 33 caps for Uruguay, and represented the nation at the 2002 World Cup.De los Santos was born in Salto.After winning three consecutive Primera División titles with Peñarol he moved to Spain, where he represented CP Mérida, Málaga CF (achieving La Liga promotion in 1999), Valencia CF – appearing in 13 matches for the 2002 league champions – Atlético Madrid and RCD Mallorca; at the latter club, he reunited with former Valencia teammate Jorge López, who had also been loaned shortly before.