 By contrast, high blood levels of insulin, due to a high carbohydrate meal or insulin resistance, strongly induces SREBP-1c expression in the liver.The reduction of adipose tissue "de novo" lipogenesis, and the increase in liver "de novo" lipogenesis due to obesity and insulin resistance leads to fatty liver disease.Fructose consumption (in contrast to glucose) activates both SREBP-1c and ChREBP in an insulin independent manner.