 Lorre's next show was "The Big Bang Theory" with co-creator Bill Prady.The show follows two genius physicists with very low social skills who befriend their neighbor, an attractive, outgoing young woman with average intelligence and no college education.Each episode usually focuses on the daily lives of the men and two of their equally socially challenged yet highly brilliant friends, with a dose of absurdity from the relationship with their less educated, but socially brilliant, neighbor.