 Although glucose can be converted into glycogen in the liver, fructose invariably increases "de novo" lipogenesis in the liver, elevating plasma triglycerides, more than glucose.Moreover, when equal amounts of glucose or fructose sweetened beverages are consumed, the fructose beverage not only causes a greater increase in plasma triglycerides, but causes a greater increase in abdominal fat.DNL is elevated in non-alcoholic fatty liver disease (NAFLD), and is a hallmark of the disease.