 "De novo" lipogenesis (DNL) is the process by which carbohydrates (primarily, especially after a high-carbohydrate meal) from the circulation are converted into fatty acids, which can by further converted into triglycerides or other lipids.Acetate and some amino acids (notably leucine and isoleucine) can also be carbon sources for DNL.Normally, "de novo" lipogenesis occurs primarily in adipose tissue.