 The working conditions in the Institute of Hygiene were so poor, that Gruber attempted to resign his chair and find employment as head of a laboratory in München or at the Jenner Institute in London, under Joseph Lister.It was while in Vienna, however, that Gruber, with his English student Herbert Edward Durham (1866–1945), discovered the agglutination which gained him international fame.Gruber eventually left Vienna in 1902, and in October that year he succeeded Hans Buchner as director of the Institute for Hygiene in München.