 Such drastic increase in mRNA will increase the proportion of Tau containing four microtubule-binding repeats, which is consistent with the neuropathology described in several families with FTDP-17, a type inherited dementia.Some types of epilepsy may be brought on due to a splice site mutation.In addition to a mutation in a stop codon, a splice site mutation on the 3' strand was found in a gene coding for cystatin B in Progressive Myoclonus Epilepsy patients.