 According to a research study conducted Hutton, M et al, a missense mutation occurring on the 5' region of the RNA associated with the tau protein was found to be correlated with inherited dementia (known as FTDP-17).The splice-site mutations all destabilize a potential stem–loop structure which is most likely involved in regulating the alternative splicing of exon10 in chromosome 17.Consequently, more usage occurs on the 5' splice site and an increased proportion of tau transcripts that include exon 10 are created.