 Brandwein established a "yeshiva" in the Jewish Quarter of the Old City of Jerusalem where he taught Kabbalah.Brandwein died on February 20, 2013, aged 67, in the Hadassah Medical Center in Ein Kerem in Jerusalem, after several months' illness.He was buried in the Mount of Olives Jewish Cemetery, next to his wife, Tzipora, who had died four years previously.