 On March 16 of 1542, Heredia departed for Antioquia to annex the territory to Cartagena.There Heredia was taken prisoner himself by Sebastián de Belalcázar and sent to Panamá to stand trial for his attempts to seize control of Antioquia.Unwilling to mediate in such a delicate affair, the Royal Audience of Panama released Heredia, who returned to Cartagena.