 It has also been shown that imbalances between angiopoietin-1 and angiopoietin-2 signaling can act independently of each other.One angiopoietin factor can signal at high levels while the other angiopoieting factor remains at baseline level signaling.Angiopoietin-2 is produced and stored in Weibel-Palade bodies in endothelial cells and acts as a TEK tyrosine kinase antagonist.