 Angiopoietin-2, on the other hand, promotes cell death and disrupts vascularization.Yet, when it is in conjunction with vascular endothelial growth factors, or VEGF, it can promote neo-vascularization.Structurally, angiopoietins have an N-terminal super clustering domain, a central coiled domain, a linker region, and a C-terminal fibrinogen-related domain responsible for the binding between the ligand and receptor.