 The first new building, One Technology Place, opened in 2000, occupied by Targacept Inc., a biopharmaceutical company that was spun out of R.J. Reynolds Tobacco.The company developed drugs to treat nervous system diseases and disorders.On April 7, 2000, developer David Shannon announced plans for a three-story building on the site of Building 256-2, and in a style recalling that building, which would house the medical school's Physician Assistant program.