 Angiopoietin-1 encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa whereas angiopoietin-2 encodes a 496 amino acid polypeptide.Angiopoietin-1 and angiopoietin-2 can form dimers, trimers, and tetramers.Angiopoietin-1 has the ability to form higher order multimers through its super clustering domain.