 Research in this area is almost exclusively performed using MHV68 as KSHV and EBV (the major human pathogens of this family) do not productively infect model organisms typically used for this type of experimentation.Herpesviruses have large genomes containing a wide array of genes.Although the first ORF in these gammaherpesviruses have oncogenic potential, other viral genes may also play a role in viral transformation.