 As the river reaches its mouth, it flows adjacent to The Lakes National Park and the Gippsland Lakes Coastal Park.Major road crossings of the river, from upstream to downstream, are located on the Yarra Junction-Noojee Road east of Powelltown; the Mount Baw Baw Road east of Noojee; the Willowgrove Road south of ; the Moe-Rawson Road north of ; the Moe-Glengarry Road west of ; and the Princes Highway north of .The Latrobe River sub-catchment area is managed by the West Gippsland Catchment Management Authority.