 In December 2019, the Greek senior national team head coach Rick Pitino, stated that, "Just for the record, I would love to see Spanoulis join our national team”.Spanoulis made his debut with the senior men's Greek national basketball team, for the first time, in the summer of 2004, when he was selected by his then head coach at Maroussi, Greek basketball legend, Panagiotis Giannakis, to be a member of the Greek squad during the 2004 Summer Olympics, which were held in Athens, Greece.Spanoulis was able to play in front of his home country's fans at Helliniko Olympic Arena, as Greece was the Olympic Game's host country.