 The first monoclonal antibodies were produced in mice (substem "-o-", yielding the ending "-omab"; usually "Mus musculus", the house mouse) or other non-human organisms.Neither INN nor USAN has ever been requested for antibodies from rats (theoretically "-a-"), hamsters ("-e-") and primates ("-i-").These non-human antibodies are recognized as foreign by the human immune system and may be rapidly cleared from the body, provoke an allergic reaction, or both.