 A year after the discovery, Paul Ehrlich used the term "antibodies" (German "Antikörper") for these antitoxins.The principle of monoclonal antibody production, called hybridoma technology, was published in 1975 by Georges Köhler and César Milstein, who were awarded the 1984 Medicine Nobel Prize for their discovery together with Niels Kaj Jerne.Muromonab-CD3 was the first monoclonal antibody to be approved for clinical use in humans, in 1986.