 He helped Pope Leo X in the conquest of the Duchy of Urbino and in 1518 he was made Marshal of France.As the French governor of Milan, his severe rule gained him the people's enmity, and he had to retreat to Parma until the arrival of his brother.At the Battle of Bicocca, he commanded the cavalry force which attempted to flank Prospero Colonna; afterwards, he assumed command of the French army and was wounded.