 Viral genomic and protein components can bind variable PRRs and stimulate a signaling pathway that results in the activation of the transcription factors, which relocate to nucleus and trigger type I IFNs transcription.Because of powerful IFN stimulating properties, before recombinant IFN became available for medical use, SeV was selected, among other viruses, for the industrial large-scale IFN production.A procedure involving inactivated SeV treatment of human peripheral blood leukocytes from donors’ blood was used for this production.