 Intratumoral injection of UV irradiated and inactivated SeV resulted in an antitumor effect in a few melanoma patients with stage IIIC or IV progressive disease with skin or lymph metastasis.Complete or partial responses were observed in approximately half of injected and noninjected target lesions.The expression of some molecules that can facilitate SeV cell entry (see the “Cell receptors” section below), frequently, accelerates carcinogenesis and/or metastasis development.