 This protein is a member of the beta-defensin family of proteins that bridges innate and adaptive immune responses to a pathogen infection.In response to SeV infection, the production of hBD-1 mRNA and protein increases 2 hours after exposure to the virus in purified plasmacytoid dendritic cells or in PBMC.After viral infection in rodents, type I IFNs promote SeV clearance and speed up the migration and maturation of dendritic cells.