 US 10 bypasses the city of Waupaca to the south and junctions with WIS 22, WIS 54 and meets WIS 49 south.US 10 and WIS 49 turn eastward to Weyauwega then head south to Fremont where WIS 49 turns south and US 10 becomes a freeway at the junction with WIS 110.US 10 collects US 45 south in northwest Winnebago County for a southeast trek before US 45 splits to the south and US 10 turns east to rendezvous with WIS 441 at the junction with I-41/US 41 in Neenah.