 This induced production happens through the activation of NF-κB downstream of the mitochondrial antiviral signaling pathway and the RIG-I.The increased concentration of ICAM-1 on the cells surface increases the vulnerability of these cells to natural killer cells.It has been shown in the Namalwa cells that SeV virus stimulates an expression of many genes involved in immune defense pathways, such as type I and type II IFN signaling, as well as cytokine signaling.