 It can be assumed that NK activation and tumor suppression by UV-treated SeV are caused by interaction between HN belonging to SeV, and NKp46 and/or NKp44 receptors belonging to NK cells.SeV even after UV inactivation, being injected intratumorally, can cause tumor infiltration by dendritic cells (DCs) and CD4+ and CD8+ T, and it also can cause enhancing of anti-tumor activity of these cells.Most likely, viral hemagglutinin-neuraminidase protein, highly contributes to the effect (see ""Neuraminidase (NA) removal of sialic acid from the surface of malignant cells stimulates natural killers cells and cytotoxic T lymphocytes"" section above").