 Thus, these enzymes are also potential biomarkers of SeV-oncolytic infectivity

The fusion protein (F) of SeV is synthesized as an inactive precursor and is activated by proteolytic cleavage of the host cell serine proteases (see the section “Proteolytic cleavage by cellular proteases” below).Some of these proteases are overexpressed in malignant neoplasms.For example, transmembrane serine protease 2 (TMPRSS2), which is an F-protein-processing enzyme, is often overexpressed in prostate cancer cells.