 In 1498, the "Confraria da Misericórdia" ("Brotherhood of the Misericórdia") was instituted, under the initiative of Eleanor of Viseu and friar Miguel Contreiras (approved by King Manuel and confirmed by Pope Alexander VI).The new institution was transferred a chapel in the cloister of the Sé Cathedral of Lisbon.In 1502, after transferring the title of the Hermitage of Restelo to the Order of Saint Jerónimo, King Manuel traded to the Order of Christ the "Casa da Judiaria Grande" ("Great House of the Jewry"), a synagogue situated in Vila Nova (which was between "Rua dos Fanqueiros" and "Rua da Madalena").