 HeLa cells can be infected with SeV; however, incubation of these cells with IFN-beta causes inhibition of SeV replication.Multiple interferon stimulated genes (ISG) were identified as being required for this inhibition including IRF-9, ZNFX1, TRIM69, NPIP, TDRD7, PNPT1 and so on.One of this genes TDRD7 was investigated in more detail.