 US 10 then enters Pepin County
and junctions with WIS 25 and WIS 85 at Durand US 10 briefly enters Buffalo County and passes through Mondovi at the junction with WIS 37.In northern Trempealeau County, the highway crosses WIS 93 at Eleva, passes through Strum, and junctions with US 53 and I-94 in Osseo.The route then enters Jackson County where it joins US 12 and WIS 27.