 Severe arrhythmias (atrial flutter and atrial fibrillation) as well as fatal cardiac arrest have also been seen which may or may be not attributed to fluid retention/increased volume.Isolated cases of stroke have been noted, those patients with previous transient ischemic attacks or partial/minor strokes may be at particular risk.Papilledema of the eyes has been observed (2%) and may lead to disturbed visual acuity and even temporary or permanent blindness.