"U-303" was no exception, managing to sink only one ship, the 4,959 ton American vessel SS "Expositor", on 23 February (which had been already crippled by "U-606" and abandoned)

Her second patrol was uneventful and very brief, simply a fourteen-day journey between Lorient and La Spezia in Italy, although it did involve passing through the heavily defended Strait of Gibraltar.She was to join a new flotilla operating in the Mediterranean Sea.