 Besides its function in the physiology of the brain, GM1 acts as the site of binding for both cholera toxin and E. coli heat-labile enterotoxin (Traveller's diarrhea).Galactosidases are enzymes that breakdown GM1, and the failure to remove GM1 results in GM1 gangliosidosis.GM1 gangliosidosis are inherited disorders that progressively destroys neurons in the brain and spinal cord as GM1 accumulates.