 Seton helped the queen to escape on the night of the murder of her secretary, David Rizzio, firstly to Seton Castle in East Lothian and then to Dunbar.When the queen's husband, Henry Stuart, Lord Darnley, was killed she again turned to Seton for help and it was in Seton Castle that the marriage contract with James Hepburn, 4th Earl of Bothwell was sealed.In 1568, when the queen was imprisoned in Loch Leven Castle it was Seton, with two hundred lancers, who aided her escape.