 His notable title defenses were two victories over former light flyweight champion Mauricio Pastrana, a decision win over Ricardo Vargas and two knockout victories over former as well as future IBO Bantamweight champion Silence Mabuza, whom he defeated for the second time on August 5, 2006 in his final defense.Márquez moved up a weight division to challenge and defeat WBC and lineal super bantamweight champion Israel Vázquez in seven rounds.However, in a rematch in July 2007, Márquez lost his title after being defeated by Vázquez in the sixth round when the referee stopped the fight.