 The M2-PK test is not dependent on occult blood (ELISA method), so it can detect bleeding or non-bleeding bowel cancer and also polyps with high sensitivity and high specificity with no false negative, but false positives may occur.Most people are more willing to accept non-invasive preventive medical check-ups.Therefore, the measurement of tumor M2-PK in stool samples, with follow-up by colonoscopy to clarify the tumor M2-PK positive results, may prove to be an advance in the early detection of colorectal carcinomas.