 This enzyme catalyses the following chemical reaction

Also acts on some related steryl sulfates.The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to the free steroid.This includes DHEA sulfate, estrone sulfate, pregnenolone sulfate, and cholesterol sulfate, all to their unconjugated forms (DHEA, estrone, pregnenolone, and cholesterol, respectively).