 In Catacamas, Castro organized the women's branch of the Liberal Party of Honduras and conducted a strong campaign in favor of her husband in the internal elections of February 2005, an occasion in which she was in charge of sub-political coordination of Catacamas.As First Lady of Honduras, Castro was in charge of social development programs, and she worked with the United Nations in coalition with other first ladies to address issues faced by women with HIV.Following the removal of her husband in the June 28, 2009 coup d'état, Castro led the movement resisting the coup d'état, repeatedly joining thousands of Hondurans in the streets calling for Zelaya's return.