 WIS 110 joins the two highway five miles east of Waupaca, and WIS 54 turns east off the route two miles (3 km) northeast of that point to continue following the river.WIS 22 and WIS 110 pass through Manawa and junction with WIS 161 west four miles (6 km) north of the city.WIS 110 continues north at that point while WIS 22 turns east and passes through the small community of Symco.