 "SHANK3" is also adjacent to a gene cluster ("ARSA" and "MAPK8IP2") that has a high probability of contributing to ASD, suggesting the effects of "SHANK3" deletion may be indistinguishable from other genetic losses.A landmark study of induced pluripotent stem cell neurons cultured from patients with 22q13 deletion syndrome shows that restoration of the "SHANK3" protein produces a significant, but incomplete rescue of membrane receptors, supporting both a substantial role for "SHANK3" and an additional role for other genes in the distal 1 Mb of chromosome 22.There is an interest in the impact of "MAPK8IP2" (also called IB2) in 22q13 deletion syndrome.