 Most of these differences involve genes that are likely associated with viral virulence and host range.Unique to Chordopoxviridae, LSDV contains homologues of interleukin-10 (IL-10), IL-1 binding proteins, G protein-coupled CC chemokine receptor, and epidermal growth factor-like protein, which are found in other poxvirus genera.LSDV mainly affects cattle and zebus, but has also been seen in giraffes, water buffalo, and impalas.