 Biological parents should be tested with fluorescence "in situ" hybridization (FISH) to rule out balanced translocations or inversions.Balanced translocation in a parent increases the risk for recurrence and heritability within families (figure 3).Clinical genetic evaluations and dysmorphology exams should be done to evaluate growth, pubertal development, dysmorphic features (table 1) and screen for organ defects (table 2)

2.