 Autoantibodies targeted to components of the basement membrane zone have been identified as pathogenic in mucous membrane pemphigoid.Antigens include 180-kD bullous pemphigoid antigen (BP180), laminin 332, beta-4-integrin, and other antigens that are not fully discovered are identified against the basement membrane.Complication of D- penicillamine therapy may trigger and causes mucous membrane pemphigoid.