 Interest in "SHANK3" grew as it became associated with autism spectrum disorder (ASD) and Schizophrenia.Since then, twelve other genes on 22q13 ("MAPK8IP2", "CHKB", "SCO2", "SBF1", "PLXNB2", "MAPK12", "PANX2", "BRD1", "CELSR1", "WNT7B", "TCF20") have been associated with autism spectrum disorder and/or Schizophrenia (see references below).Some mutations of "SHANK3" mimic 22q13 deletion syndrome, but "SHANK3" mutations and microdeletions have quite variable impact.