 By definition, males have small, mobile gametes (sperm); females have large and generally immobile gametes (ova or eggs).In humans, typical male or female sexual differentiation includes the presence or absence of a Y chromosome, the type of gonads (ovary or testes), the balance of sex hormones (testosterone and estrogen), the internal reproductive anatomy (e.g.uterus or prostate gland), and the external genitalia (e.g.