 Rodionova reached her career-high singles ranking of world No.62 on 16 August 2010.Immediately following the Cincinnati Masters, she played her next tournament at the Pilot Pen Tennis tournament, where she entered as a qualifier and defeated Tsvetana Pironkova in the first round 6–1, 7–5, but lost to sixth seed Marion Bartoli 3–6, 1–6 in the second.