 Descending the mountain, PA 378 bends northwestward as a four lane arterial known as Wyandotte Street until leaving the University Heights area near Holy Ghost Cemetery.PA 378 continues into the city of Bethlehem, where it turns northward into residential areas as a two-lane road and is called Wyandotte Street.In the South Side section of the city, PA 378 intersects with the northern terminus of PA 412 (Broadway).