 The route crosses the Lehigh River and becomes a four-lane freeway that continues north to US 22.PA 378 is the only highway from US 22 to Center City Bethlehem, and a quick route for visitors traveling to the Wind Creek Bethlehem casino resort on the city's South Side.The portion of PA 378 south of Bethlehem was originally numbered as PA 12 in 1928 and renumbered to PA 191 in 1961.