 Set in Cleveland, much of the film was shot on location at well-known Cleveland area landmarks such as Coventry Village and Case Western Reserve University.Frustrated with the fact that he cannot give his wife Priscilla (Parker Posey) an orgasm, Jack (Paul Rudd) moves out of the house and starts a relationship with Kristen (Mischa Barton), his student.Unfulfilled, Priscilla forms an unlikely partnership with Wayne (Danny DeVito), a businessman more than twice her age.