 Systems approach is a method used to study myogenesis, which manipulates a number of different techniques like high-throughput screening technologies, genome wide cell-based assays, and bioinformatics, to identify different factors of a system.This has been specifically used in the investigation of skeletal muscle development and the identification of its regulatory network.Systems approach using high-throughput sequencing and ChIP-chip analysis has been essential in elucidating the targets of myogenic regulatory factors like MyoD and myogenin, their inter-related targets, and how MyoD acts to alter the epigenome in myoblasts and myotubes.