 The manager of River Plate wanted to have Scocco as soon as possible, as he would replace Sebastián Driussi who joined FC Zenit Saint Petersburg for €20 million.On 4 July 2017, he made his debut in the club as a starter in a 2–0 away win against Guarani FC in the 2017 Copa Libertadores.On 21 September 2017, he scored five goals for River Plate in their 8-0 comeback home 2017 Copa Libertadores quarterfinals win against Bolivian side Jorge Wilstermann.