 Manfredini spent four seasons with different sides, playing in both Serie C1 and C2 until he was sent to Cosenza in 1998 where he made his debut in Serie B at the age of 23.In 1999, after a year with Cosenza, Manfredini joined Genoa, for 700 million lire or €361,520 (50% rights), also in Serie B at the time.After just a season with Genoa, Manfredini then joined a club which was making its way forward on the Italian football scene.