 After being a member of Italy's 2003 Under-19 European Championship winning squad, Palladino went on to represent his country at Under-21 level, taking part at the 2006 and 2007 Under-21 European Championships, scoring a goal against Denmark in 2006; in total he made 15 appearances for the "azzurrini", scoring 4 goals.He received his first call-up to the senior team on 17 November 2007, under the direction of manager Roberto Donadoni, for Italy's European qualifier against Scotland, but did not play in the game.His debut came just a few days later, at the age of 23, in a 3–1 home win against the Faroe Islands, on 21 November 2007.