 Broken chromosomes that lead to acentric and dicentric fragments can be studied in "S. cerevisiae" due to its known ability to tolerate aneuploidy, an abnormal number of chromosomes.Strains of "S. cerevisiae" that tolerate aneuploidy can stabilize products of broken chromosomes during proliferation, which can be recovered and studied in a laboratory setting.Cytogenetics

Centromere function has been the focus of many laboratory analyses, involving techniques like fluorescence "in situ" hybridization (FISH) and chromosomal banding (C-banding).