 "Me & U" was released as the lead single from the album on May 16, 2006, peaking in the top ten of several charts, having spent a month at number three on the US "Billboard" Hot 100 and seven weeks atop the US Airplay chart, receiving a Platinum certification by the Recording Industry Association of America selling over one million digital downloads.The official music video for the track featured Cassie in a solo dance rehearsal, which drew comparisons to Janet Jackson's "The Pleasure Principle" visuals from 1987.Cassie, a fan of Jackson, explained the concept came from Mottola and Diddy who suggested the idea after watching her rehearsal videos dancing alone in front of the mirror.