 The formation of dicentric chromosomes and their implications on centromere function are studied in certain clinical cytogenetics laboratories.Most dicentric chromosomes are known to form through chromosomal inversions, which are rotations in regions of a chromosome due to chromosomal breakages or intra-chromosomal recombinations.Inversions that exclude the centromere are known as paracentric inversions, which result in unbalanced gametes after meiosis.