 On 13 September 2015, he scored two goals in his debut for Lazio in the 64th minute, followed by the 73rd minute to triumph 2–0 over Udinese.On 16 August 2016, Matri transferred to Sassuolo on a permanent deal.On 2 September 2019, on the last day of the summer transfer window, Matri joined newly promoted club Brescia on a single-season loan with the option for a second.