 He named it "vagusstoff" ("vagus substance"), noted it to be a structural analog of choline and suspected it to be acetylcholine.In 1926, Loewi and E. Navratil deduced that the compound is probably acetylcholine, as vagusstoff and synthetic acetylcholine lost their activity in a similar manner when in contact with tissue lysates that contained acetylcholine-degrading enzymes (now known to be cholinesterases).This conclusion was accepted widely.