 If a melanocytic nevus is suspected of being a melanoma, it needs to be sampled or removed and sent for microscopic evaluation by a pathologist by a method called skin biopsy.One can do a complete excisional skin biopsy or a punch skin biopsy, depending on the size and location of the original nevus.Other reasons for removal may be cosmetic, or because a raised mole interferes with daily life (e.g.