 Resistance to macrolides in "T. Pallidum" strain 14 is believed to derive from a single point mutation that increased the organisms livability.Many of the syphilis treatment therapies only lead to bacteriostatic results, unless larger concentrations of penicillin are used for bactericidal effects.Penicillin overall is the most recommended antibiotic by the CDC as it shows the best results with prolonged usage, it can inhibit and may even kill "T. Pallidum" at low to high doses with each increase in concentration being more effective.