 This was a revelation, as it showed for the first time that genes, even in an organism as small as a bacterium, were subject to fine-grained control.The implication was that many other genes were also elaborately regulated.In 1977, a revolution in thinking about evolution and developmental biology began, with the arrival of recombinant DNA technology in genetics, and the works "Ontogeny and Phylogeny" by Stephen J. Gould and "Evolution by Tinkering" by François Jacob.