 The strengthening of the Inquisition continued under Paul IV, and few could consider themselves safe by virtue of position in his drive to reform the Church; even cardinals he disliked could be imprisoned.He appointed inquisitor Michele Ghislieri, the future Pope Pius V, to the position of Supreme Inquisitor despite the fact as Inquisitor of Como, Ghislieri's persecutions had inspired a citywide rebellion, forcing him to flee in fear for his life.On 17 July 1555, Paul IV issued one of the most infamous papal bulls in Church history.