 Proteases occur in all organisms, from prokaryotes to eukaryotes to viruses.These enzymes are involved in a multitude of physiological reactions from simple digestion of food proteins to highly regulated cascades (e.g., the blood-clotting

Protease containing plant-solutions called vegetarian rennet has been in use for hundreds of years in Europe and middle-east for making kosher and halal Cheeses.Vegetarian rennet from "Withania coagulans" has been in use for thousands of years as Ayurvedic remedy for digestion and diabetes in the Indian subcontinent.