 As of June 2006, the TB Structural Genomics Consortium consists of 430 active members in 148 laboratories from 83 institutions across 15 countries.Consortium laboratories are collectively responsible for 3.3% of all protein structures in the protein data bank and have extensive records of methods development.Consortium members have carried out a pilot project on the structural genomics of a hyperthermophile that has identified bottlenecks in the structure determination process and resulted in the development of methodologies for high-throughput structure determination and analysis.