 If a bacterium is resistant to a sulfonamide, it is resistant to all the forms.Furthermore, sulfacetamide is toxic to soil organisms.Sulfacetamide is synthesized either by direct alkylation of acetamide with 4-aminobenzenesulfonyl chloride, or by reacting 4-aminobenzenesulfonamide with acetic anhydride and subsequent selective, reductive deacylation of the resultant acetamide using a system of zinc-sodium hydroxide.