 WIS 25 terminates at WIS 48 seven miles (11 km) north of Barron, or five miles (8 km) east of Rice Lake

The original alignment of WIS 25 was along the present-day route from Nelson to Menomonie.From Nelson southward, WIS 25 followed the routing of present-day WIS 35 to junction with then WIS 52 at Galesville.The route was truncated at Durand in the early 1920s and also extended to end at then STH-14 (present day US 8) and to WIS 48 a few years later.