 Wyre began his performance career as a percussionist with the Oklahoma City Symphony Orchestra in 1964-1965 and the Milwaukee Symphony Orchestra in 1965-1966.He then immigrated to Canada to become a timpanist with the Toronto Symphony Orchestra, serving in that capacity from 1966–1971 and again from 1975-1981.In 1971 he co-founded the percussion ensemble Nexus with whom he remained active until 2002.