 WIS 25 junctions with WIS 72 in Downsville six miles (10 km) north of the county line.After another seven miles (11 km), WIS 25 enters Menomonie, junctions with WIS 29 near the University of Wisconsin–Stout campus and joins US 12 in the downtown area near Lake Menomin.WIS 25 splits from US 12 after a one-mile (1.6 km) concurrency with US 12 turning northwest.