 On December 2, 2006, Clottey earned his first shot at a world title but broke his hand in the fourth round of his fight against World Boxing Organization champion Antonio Margarito.That bout against Margarito has since come under controversial suspicion following news reports (released after Margarito's fight with Shane Mosley) that Margarito had boxed opponents with hand wraps illegally loaded with plaster (along with Margarito's first bout with Miguel Cotto).On April 7, 2007 (following Clottey's questionable loss to Margarito), Clottey earned a unanimous decision over Diego Corrales, in what was Corrales's final fight before his death.