 He was court painter to Duke of Urbino Federico da Montefeltro and painted several altarpieces, two now in the Berlin Museum, a Madonna in the church of San Francesco in Urbino, one at the church of Santa Croce in Fano, one in the National Gallery at London, and another in the gallery at Urbino; an Annunciation at the Brera in Milan; a resurrected Christ in the Museum of Fine Arts, Budapest; and a Jerome in the Lateran.The reputation of the court had been established by Federico da Montefeltro.The emphasis of Federico's court was more literary than artistic, but Santi was a poet of sorts as well as a painter, and had written a rhymed chronicle of the life of Federico, and both wrote the texts and produced the decor for masque-like court entertainments.