 Later that century, the town became the seat of an "Amt" and a "Centgericht" of the Prince-Bishop of Würzburg.Seßlach was part of the "Hochstift Würzburg" until secularization in 1803.Over the centuries, the town suffered more under the German Peasants' War (1525) than nearby Coburg and was also damaged and plundered during the Thirty Years' War, the Seven Years' War and the Napoleonic Wars.