 Nelson has focused on five primary topics of research, generally categorized in two areas, "Scientific Research" and "America's Scientific Readiness".Within Scientific Research, Nelson's topics have been on mechanistic patterns in alkene addition reactions and on Single-Walled Carbon Nanotube (SWCNT) functionalization and analysis, yielding the first COSY NMR spectrum of covalently functionalized SWCNTs in solution.Under America's Scientific Readiness, she focuses on science education, which includes classroom innovations and correcting organic chemistry textbook inaccuracies, on ethnic and gender diversity (the Nelson Diversity Surveys) among highly ranked science departments of research universities, and on improving the image and presentation of science and scientists to the public.