 Serving as the southernmost west–east thoroughfare of the parish, it intersects LA 47 (Paris Road) and LA 3238 (Palmisano Boulevard) in Chalmette.Continuing eastward, the highway again meets LA 39 at Bayou Road and runs concurrently for two miles (3 km) near the end of East Judge Perez Drive, at which point LA 46 turns east through the community of Reggio and LA 300.From there, LA 46 connects to the towns of Yscloskey (via LA 625), Shell Beach, and Hopedale (via LA 624) before ending at a dead end with the Mississippi River-Gulf Outlet Canal.