 Safi served as Executive Director of the Islamic Society of North America (ISNA), an unindicted co-conspirator to terror finance in the Holy Land Foundation Trial, Leadership Development Center (ILDC) (2004–2008), later he served as Director of Communications and Leadership for year 2009.He serves on the board of Muslim organizations, including the Center for the Study of Islam and Democracy (CSID), and the Association of Muslim Social Scientists (AMSS).He is a fellow with the Institute of Social Policy and Understanding (ISPU) and serves on the steering committee of the Muslim-Christian Initiative on the Nuclear Weapons Danger (MCI).