 Safi has served as Executive Director and Director of Research for the Muslim Brotherhood-funded think tank International Institute of Islamic Thought (IIIT), editor of the Journal of Islamic Social Sciences, and President of the Association of Muslim Social Scientists (1999–2003).He has also taught at Wayne State University in Detroit, Michigan, the International Islamic University in Malaysia and George Washington University in Washington, DC.Safi served as Executive Director of the Islamic Society of North America (ISNA), an unindicted co-conspirator to terror finance in the Holy Land Foundation Trial, Leadership Development Center (ILDC) (2004–2008), later he served as Director of Communications and Leadership for year 2009.