 On 25 November 1577, Mohammad Khodabanda's younger brother Ismail II died abruptly and without any initial signs of bad health.The court doctors, who checked the corpse, surmised that he may have died from poison.The general agreement was that his half-sister Pari Khan Khanum had resolved to have poisoned with the help of the mistresses of the inner harem in retaliation for his bad behaviour towards her.