 Upon further study, this case proved to be important because it demonstrated that "SOD1" mutations might not effect steady neuropathological changes, and that environmental and genetic factors might affect the phenotype of the SOD1 mutations.PBP is aggressive and relentless, and there were no treatments for the disease as of 2005.However, early detection of PBP is the optimal scenario in which doctors can map out a plan for management of the disease.