 The Port of Indiana–Burns Harbor handles more ocean-going cargo than any other Great Lakes port in the U.S. Gambling is another important component to the Calumet region's economy, with five riverboat casinos on Lake Michigan (Ameristar, Blue Chip, Horseshoe, Majestic Star, and Majestic Star II).The north central area of Northern Indiana, centered on Warsaw, is home to several companies specializing in the development and production of orthopaedic medical devices.Nearly one-third of the $38 billion global orthopaedic industry is concentrated in north central Indiana.