 DeSanto moved to Chicago and signed with Chess Records in 1962 as a recording artist and writer.Among her recordings for Chess were "Slip-in Mules", "Use What You Got", "Soulful Dress" (her biggest hit for Chess), and "I Don't Wanna Fuss".DeSanto participated in the American Folk Blues Festival tour of Europe in 1964, and her lively performances, including wild dancing and standing back flips, were widely appreciated.