 On 2010, the unit was deployed to the Gulf of Aden for anti-piracy operations against pirates along the Somali coast.With 1st Battalion, 4th Marines as detachment, they were responsible for the 9 September recapturing of MV "Magellan Star"

On 17 September 2012, the 15th MEU was deployed with the "Peleliu" Amphibious Ready Group (, , and as a theater reserve and crisis response force throughout the U.S. Central Command and the U.S. 5th Fleet area of responsibility.The unit returned to Camp Pendleton 13 May 2013.