 Rapid bolus infusion of acecainide has been associated with serious hypotension and a maximum infusion rate of 50 mg/min has been suggested.Intravenous infusion of 0.45 mg/kg/min for 30 minutes, followed by 0.22 mg/ml/min for 30 minutes and a maintenance infusion, suppressed more than 90% of PVCs.Doses of acecainide 15 to 20 mg/kg were also effective in preventing induced ventricular tachycardia or prolonging ventricular tachycardia cycle length and reducing frequency of PVCs.