 Renal clearance of acecainide following short and long term administration ranges from 2.08±0.36 mL/min/kg to 3.28±0.52 mL/min/kg in healthy people.There is a linear relationship between acecainide clearance and creatinine clearance.However, the clearance of acecainide was reduced in a few patients with cardiomyopathyand and ventricular arrhythmias.