 In classic non-deforming osteogenesis Imperfecta with blue sclerae or common variable osteogenesis Imperfecta with normal sclerae, nearly 60% of cases are de novo.COL1A1/2-related osteogenesis Imperfecta is identified by repeated fractures with trivial trauma, defective dentinogenesis imperfecta (DI), and hearing loss.The clinical features of COL1A1/2-related osteogenesis Imperfecta can be highly variable ranging from severe and lethal perinatal fractures to individuals with minimal tendency to repeated fractures and skeletal deformities and with a normal stature and life span.