 PAI-2 provides protection for cancer cells against plasmin-induced cell death, which can exert a lethal effect on tumors.This protection is particularly salient in brain metastases, which tend to express high levels of PAI-2 and neuroserpin, and whose growth may be partially inhibited by knockout of PAI-2.Due to its high expression in tumor cells, PAI-2 has been used to track and study the spread of angiotropic melanoma cells.