 The relationship between pain and itch is evident in the fact that itch sensations occur along a similar neurological and sensory pathway as sensations of pain, and the fact that individuals who are insensitive to pain are also insensitive to itch.Itch is induced by mechanical, chemical, thermal, or electrical stimuli of sensory receptors in the peripheral nervous system, or by psychological prompts.The receptors that are responsible for the sensation of itch caused by environmental stimuli are found within the upper layers of the skin.