 Up to this point, the most convincing evidence points toward the thalamus, sympathetic nervous system, and chemical signals (like histamine) as the major aspects of our physiology responsible for the phenomenon, as explained above.Increasing knowledge of itching in general and its similarities with pain in the future could help to reveal some of what is unknown about referred itch, as could a better understanding of histamine and the C-fibers' involvement with itch sensations.Without question, there is a need for further experimentation and study to be directed at referred itch, particularly as the body of evidence pertaining to it is scattered and often inconclusive.