 The road passes through the limits of the cities and towns of Kenova, Ceredo, Huntington, Barboursville, Milton, Hurricane, St. Albans, South Charleston, Charleston, Belle, Cedar Grove, Glasgow, Smithers, Gauley Bridge, Ansted, Rainelle, Rupert, Lewisburg, and White Sulphur Springs, as well as in or near the smaller communities of Ona, Culloden, Amandaville, Jefferson, Malden, Rand, Dupont City, Diamond, Shrewsbury, Hugheston, London, Boomer, Falls View, Charlton Heights, Glen Ferris, Chimney Corner, Victor, Hico, Lookout, Hilton Village, Charmco, Hines, Crawley, Sam Black Church, Clintonville, Alta, and Caldwell.The route exits the state into Virginia concurrent with Interstate 64 east of White Sulphur Springs.Most of US 60's route through West Virginia is part of and even signed in several areas as the Midland Trail.