 In 1608, Maria Maddalena was married to Cosimo de' Medici, Grand Prince of Tuscany.Cosimo's father, Grand Duke Ferdinando I of Tuscany, arranged the marriage in order to assuage Spain's (where Maria Maddalena's sister was the incumbent queen) animosity towards Tuscany, which had been inflamed due to a string of Franco-Tuscan marriages.She and Cosimo enjoyed a contented marriage.