 The northern terminus is at PA 443 north of Lickdale in Union Township.PA 72 serves as a major road connecting Lancaster and Lebanon counties, serving East Petersburg, Manheim, Cornwall, Lebanon, and Jonestown.The route intersects several major roads including US 30 and PA 283 north of Lancaster, the Pennsylvania Turnpike (Interstate 76, I-76) south of Cornwall, US 322 along a freeway bypassing Cornwall, US 422 in Lebanon, US 22 near Jonestown, and I-81 via Fisher Avenue in Lickdale.