 Northbound PA 72 begins at an intersection with northbound US 222/PA 272 in the city of Lancaster in Lancaster County, heading north on South Queen Street, which carries two lanes of one-way traffic northbound.The road passes through urban areas of rowhomes and businesses before it reaches the commercial downtown of Lancaster.The route passes to the west of the Lancaster County Convention Center before it intersects King Street, which carries eastbound PA 462, at Penn Square, where the Soldiers and Sailors Monument is located.