 In 1928, PA 72 was extended north from Lancaster to PA 343 north of Jonestown; also, US 222 replaced the US 230 designation that was concurrent with the route between the Maryland border and Lancaster.PA 72 followed US 222 from the Maryland border north through Quarryville to Lancaster, where it continued north along its current alignment to Quentin.Here, it turned east along PA 5 (later US 322, now PA 419) to Cornwall and then north along Cornwall Road to Lebanon.