 Northbound PA 72 continues through the downtown area along North Queen Street, crossing eastbound PA 23 at Chestnut Street and westbound PA 23/PA 462 at Walnut Street; the road passes west of the Queen Street Station serving RRTA buses between Chestnut and Walnut streets.The road leaves downtown Lancaster and continues through urban areas of homes and commercial establishments, passing to the west of Lancaster General Hospital.The route crosses into Manheim Township at the Liberty Street intersection and comes to an intersection with southbound US 222/PA 272 at McGovern Avenue to the south of the Lancaster station along Amtrak's Keystone Corridor.