 PA 72 was split into a one-way pair in Lancaster in the 1950s, with the northbound direction following Queen Street and the southbound direction following Prince Street.Northbound PA 72 ran concurrent with northbound US 222 on Queen Street up to Church Street, where US 222 split northeast on that street before continuing north on Lime Street, while southbound PA 72 ran concurrent with southbound US 222 on Prince Street through the length of the city.Also, the route was split into its current one-way pair in downtown Lebanon, with both directions having previously followed 9th Street.