 The route was moved to its current alignment between Quentin and Lebanon in the 1950s, having previously followed US 322 along what is now PA 419 between Quentin and Cornwall and Cornwall Road north to Lebanon.PA 72 was also split into one-way pairs following Queen and Prince streets in Lancaster and 9th and 10th streets in Lebanon.The route around Cornwall was upgraded to a freeway bypass concurrent with US 322 in 1963.