 MacFarlane uses his own voice while portraying Brian.MacFarlane also provides the voices for various other recurring and one-time only characters, most prominently those of neighbour Glenn Quagmire, news anchor Tom Tucker, Lois' father Carter Pewterschmidt and Dr. Hartman.He explained on the Graham Norton Show that the voice for Glenn Quagmire is based on 1940s and 1950s radio commercials.