 The highway passes by Weyauwega and the Waupaca Municipal Airport before leaving the concurrency and running through Waupaca.After exiting Waupaca, it runs north to Scandinavia and then to Iola, where the highway enters runs concurrently for a short distance with WIS 161.WIS 49 then runs northwesterly to WIS 66 before continuing north, passing through an intersection with WIS 153 in Elderon before terminating at WIS 29.