 This binding often results in deactivation of the second transcription factor in a process known as transrepression.One example of a nuclear receptor that are able to transrepress is the glucocorticoid receptor (GR).Furthermore, certain GR ligands known as Selective Glucocorticoid Receptor Agonists (SEGRAs) are able to activate GR in such a way that GR more strongly transrepresses than transactivates.