 Studies suggest that colicky infants treated with "L. reuteri" experience a reduction in time spent crying compared to those treated with simethicone or placebo.However, colic is still poorly understood, and it is not clear why or how "L. reuteri" ameliorates its symptoms.One theory holds that affected infants cry because of gastrointestinal discomfort; if this is the case, it is plausible that "L. reuteri" somehow acts to lessen this discomfort, since its primary residence is inside the gut.