 During the 1950 midseason, New York sent Pillette to the St. Louis Browns along with Jim Delsing, Don Johnson, Snuffy Stirnweiss and cash consideration in exchange for Tom Ferrick, Joe Ostrowski and Leo Thomas.In 1951, while pitching for the Browns, Pillette led the American League in losses with 14, joining his father Herm, who also led the league with 19 losses while pitching for the 1923 Tigers.Pillette pitched for the Browns until 1953, and was part of the Orioles from 1954 to 1955 after the franchise moved to Baltimore, Maryland.