 Endocervical adenocarcinoma, like cervical cancer (squamous cell carcinoma), often arises in the milieu of human papilloma virus infection.As most endometrial cancers are adenocarcinomas, differentiation of endocervical adenocarcinoma and endometrial adenocarcinomas is required, as the treatment differs.Immunohistochemical staining is often helpful in this regard, endocervical adenocarcinomas are typically CEA and p16 positive and estrogen receptor, progesterone receptor and vimentin negative.