 He returned to Sampdoria in January 2006, due to injuries of Emiliano Bonazzoli, when he made 12 appearances, without a goal.In June 2006, Atalanta gave up the remain registration rights of Colombo to Sampdoria for free, while the "Blue-Black" also forced to sell Biagio Pagano to Sampdoria after no agreement was formed and a lower bid thereafter .But it saw Colombo sent to Brescia (Serie B) in a co-ownership deal on 29 August 2006, for a peppercorn fee of €500.