 In 2014 he was 7-2 with six saves and a 1.87 ERA, and 68 strikeouts in 67.1 innings.Despite having only given up 4 home runs the entire season, Neshek surrendered a postseason game-losing home run in Game 2 of the 2014 National League Division Series to Matt Kemp of the Los Angeles Dodgers and the game-tying home run in Game 5 of the 2014 National League Championship Series to Michael Morse of the San Francisco Giants, which ultimately lead to the elimination of the Cardinals in the 2014 postseason.On December 10, 2014, Neshek agreed to a two-year, $12.5MM contract with the Houston Astros.