 MD 6 intersects US 301 (Robert Crain Highway) on the west side of downtown La Plata.The state highway continues east as Charles Street, which passes by the Charles County courthouse, county offices, and the two streets that formed the original alignment of US 301, St. Mary's Avenue heading south and Washington Avenue, which heads north past The Hermitage.MD 6 intersects CSX Transportation's Pope's Creek Subdivision at grade, then leaves the downtown area and continues east past the University of Maryland Charles Regional Medical Center and over Clark Run.