 The United States and Canada are the only countries which permit furosemide use during racing.Other vascular agents such as nitric oxide (NO), n-nitro-l-arginine methyl ester (L-Name), nitroglycerin, NO + phosphodiesterase inhibitors (e.g., sildenafil), and endothelin receptor antagonists have no effect, and in some cases worsen of the EIPH.A non-pharmacological nasal strip, applied prophylactically, variably reduces EIPH, depending on the severity of EIPH in an individual horse, and the duration and intensity of the exercise bout.