 However, the cell line is appreciated to be N-type (neuronal), given its morphology and the ability to differentiate the cells into along the neuronal lineage (in contrast to the S-type SH-EP subcloned cell line, also derived from SK-N-SH).Cells with short spiny neurite-like processes migrate out from these adherent clumps.SH-SY5Y cells possess an abnormal chromosome 1, where there is an additional copy of a 1q segment and is referred to trisomy 1q.