 In the asymmetric synthesis of the "Lycopodium" alkaloid huperzine-Q, Takayama and co-workers used an intramolecular Pauson–Khand reaction to cyclise an enyne containing a "tert"-butyldiphenylsilyl (TBDPS) protected primary alcohol.The preparation of the cyclic siloxane moiety immediately prior to the introduction of the dicobalt octacarbonyl ensures that the product is formed with the desired conformation.Hydrogenation of Co2(CO)8 produces cobalt tetracarbonyl hydride, [HCo(CO)4]