 SH-SY5Y cells are often used as "in vitro" models of neuronal function and differentiation.They are adrenergic in phenotype but also express dopaminergic markers and, as such, have been used to study Parkinson's disease, neurogenesis, and other characteristics of brain cells.SH-SY5Y was cloned from a bone marrow biopsy derived line called SK-N-SH and first reported in 1973.