 MD 6 connects several small communities in southern Charles County and northern St. Mary's County with U.S. Route 301 (US 301) in La Plata, the county seat of Charles County, and MD 5 in Charlotte Hall.The state highway also provides access to multiple historic sites around Port Tobacco, the original county seat of Charles County.MD 6 was one of the original highways numbered by the Maryland State Roads Commission in 1927.