 This will show the presence of clusters of differentiation, cell surface proteins - namely CD30, with CD19, CD20 and CD22, and with the absence of CD15.Other markers may also be used to confirm the diagnosis.Treatment usually includes the typical regimens of CHOP or EPOCH or other regimens; regimens generally including cyclophosphamide, an anthracycline, prednisone, and other chemotherapeutics; and potentially also a stem cell transplant.