 In 435, Theodosius II sent him into exile in Upper Egypt, where he lived on until 450, strenuously defending his orthodoxy.His last major defender within the Roman Empire, Theodoret of Cyrrhus, finally agreed to anathematize him in 451 during the Council of Chalcedon.From then on, he had no defenders within the empire, but the Church of the East never accepted his condemnation.