 The central and southwestern portions of Clay County, from west of Bluffton to northwest of Coleman, are located in the Lower Chattahoochee River sub-basin of the ACF River Basin (Apalachicola-Chattahoochee-Flint River Basin).The county's northwestern corner, which is bisected by State Route 39 running north from Fort Gaines, is located in the Middle Chattahoochee River-Walter F. George Lake sub-basin of the same ACF River Basin.Just the very southeastern corner of Clay County is located in the Spring Creek sub-basin of the same larger ACF River Basin.