 Valproic acid has been found to directly stimulate androgen biosynthesis in the gonads via inhibition of histone deacetylases and has been associated with hyperandrogenism in women and increased 4-androstenedione levels in men.High rates of polycystic ovary syndrome and menstrual disorders have also been observed in women treated with valproic acid.The vast majority of valproate metabolism occurs in the liver.