 In the U.S., Lyme is most common in the New England and Mid-Atlantic states and parts of Wisconsin and Minnesota.The first sign of about 80% of Lyme infections, typically one or two weeks after a tick byte, is usually an expanding rash that may be accompanied by headaches, body aches, fatigue, or fever.In up to 10–15% of Lyme infections, facial palsy appears several weeks later, and may be the first sign of infection that is noticed, as the Lyme rash typically does not itch and is not painful.