 Transmitted by the sandfly, the protozoan parasites of "L. major" may switch the strategy of the first immune defense from eating/inflammation/killing to eating/no inflammation/no killing of their host phagocyte and corrupt it for their own benefit.They use the willingly phagocytosing polymorphonuclear neutrophil granulocytes (PMNs) rigorously as a tricky hideout, where they proliferate unrecognized from the immune system and enter the long-lived macrophages to establish a "hidden" infection.Upon microbial infection, PMNs move out from the bloodstream through the vessels’ endothelial layer, to the site of the infected tissue (dermal tissue after fly bite).