 The morphology of cells with suppressed microtubule dynamics indicate that cells can extend the front edge (polarized in the direction of movement), but have difficulty retracting their trailing edge.On the other hand, high drug concentrations, or microtubule mutations that depolymerize the microtubules, can restore cell migration but there is a loss of directionality.It can be concluded that microtubules act both to restrain cell movement and to establish directionality

Microtubules have a major structural role in eukaryotic cilia and flagella.