 Subsequently, it was determined that modafinil binds to the same site on the DAT as cocaine, but in a different manner.In accordance, modafinil increases locomotor activity and extracellular dopamine concentrations in animals in a manner similar to the selective DRI vanoxerine (GBR-12909), and also inhibits methamphetamine-induced dopamine release (a common property of DRIs, since DAT transport facilitates methamphetamine's access to its intracellular targets).As such, "modafinil is an exceptionally weak, but apparently very selective, [DAT] inhibitor".