 Generation of pressure is dependent on formin-mediated F-actin nucleation and Rho kinase (ROCK)-mediated myosin II contraction, both of which are governed upstream by signaling pathways RhoA and ECT2 through the activity of Cdk1.Due to its importance in mitosis, the molecular components and dynamics of the mitotic actomyosin cortex is an area of active research.Mitotic cells irradiated with X-rays in the G1 phase of the cell cycle repair recombinogenic DNA damages primarily by recombination between homologous chromosomes.