sentences:  Liutprand, King of the Lombards enlarged it, and Emperor Otto II made it the chief town of a marquisate, giving it to the sons of Aleran, Duke of Saxony; later it was inherited by Emperor Michael VIII, Palaeologus, who sent thither his son Theodore.In 1533, the dynasty of the Palaeologi being extinct, Charles V, Holy Roman Emperor gave Casale to the House of Gonzaga.From 1681 to 1706 it was in the hands of the French, from whom, in 1713, it passed to the House of Savoy.