sentences:  TBT can locally disrupt aromatase regulation in the hypothalamus causing the responses of the HPA axis to hormones to become abnormal.TMT works in a similar but unique way, inducing NPY and NPY2 receptor expression initially which later is counteracted by neuronal degeneration in lesions causing decrease in signaling ability.While an increase in food intake is often the case after exposure, weight gain involves the body's maintenance of its metabolic setpoint as well.