sentences:  Obesogens that target the PPARγ/RXR complex mimic the metabolic ligands and activate the receptor leading to upregulation of lipid accumulation which explains their obesogenic effects.However, in the case of obesogens that target the PPARα/RXR complex, which when stimulated reduces adipose mass and body weight, there are a few explanations as to how they promote obesity.The ligand binding pockets of PPARs are very large and unspecified, allowing for different isoforms of the receptor (PPARα, δ, and γ) to be activated by the same agonist ligands or their metabolites.