sentences:  Dogs are the exception – since they are unable acetylate sulfanamides, they excrete sulfadimethoxine mostly unchanged in the urine (their inability to transform sulfadimethoxine also makes them more susceptible to negative side effects).Sulfadimethoxine has a relatively high solubility at the pH normally occurring in the kidneys, and is easily reabsorbed into the renal tubules, adding to its long half-life.The use of sulfadimethoxine raises concerns that it will precipitate in the kidneys, leading to crystalluria.