sentences:  The glucose acts as an osmotic diuretic (this effect is the cause of polyuria in diabetes) which can lead to dehydration.The increased amount of glucose in the urine can also worsen the infections already associated with diabetes, particularly urinary tract infections and thrush (candidiasis).Rarely, use of a SGLT2 drug, including dapagliflozin, is associated with necrotizing fasciitis of the perineum, also called Fournier gangrene.