sentences:  DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution, having diverged from DRB1 approximately 4 million years ago.DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.DR52 serotype is positively associated with systemic sclerosis, inflammatory myopathies, inclusion body myositis,
  
  DRB3*01 is positively associated with sarcoidosis, Grave's Disease, pulmonary sarcoidosis,
  
  DRB3*0101