sentences:  Previous treatment options for multiply relapsed aggressive non-Hodgkin lymphoma had disappointing response rates.The completed phase II RAPID trial compared the CHOP-R regimen of Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, and Rituximab to the same regimen, but substituting Doxorubicin with Pixantrone.The objective was to show that Pixantrone was not inferior to Doxorubicin and less toxic to the heart.