sentences:  Levitzki demonstrated (1993) that such an inhibitor of Bcr-Abl kinase induces death of chronic myeloid leukemia (CML) cells.This work led to the development of Gleevec by Novartis (1996) that is currently used, with great success, for therapy of patients afflicted by this disease.Levitzki also pioneered the inhibitors of EGF receptor, PDGF receptor, Her-2/neu, Jak-2, VEGFR and peptide based cell permeable PKB/Akt inhibitors.