sentences:  This protease cleaves PARP-1 into two fragments, leaving it completely inactive, to limit poly-ADP-ribose production.One of its fragments migrates from the nucleus to the cytoplasm and is thought to become a target of autoimmunity.During caspase-independent apoptosis, also called parthanatos, poly-ADP-ribose accumulation can occur due to activation of PARPs or inactivation of poly(ADP-ribose) glycohydrolase, an enzyme that hydrolyses poly(ADP-ribose) to produce free ADP-ribose.