sentences:  In 1995 Velculescu developed SAGE (serial analysis of gene expression), a gene expression technology for the global and quantitative measurement of gene activity.The SAGE approach provided some of the first insights into gene expression patterns in eukaryotic cells and the identification of gene expression patterns in human cancer.These studies led Velculescu to coin the term transcriptome in a 1997 paper to describe the comprehensive gene expression patterns that could now be analyzed.