sentences:  A combination of factors, including disease, land disputes between the Choctaw and Cherokee, and pressures from the United States government had largely depopulated the area by the time Revolutionary War veteran John Hunt settled in the land around the Big Spring in 1805.The 1805 Treaty with the Chickasaws and the Cherokee Treaty of Washington of 1806 ceded native claims to the United States government.The area was subsequently purchased by LeRoy Pope, who named the area Twickenham after the home village of his distant kinsman Alexander Pope.