sentences:  In particular, Ephrin-B2 and EphB4 determine the arterial and venous fate of endothelial cells, respectively, though regulation of angiogenesis by mitigating expression in the VEGF signalling pathway.Ephrin-B2 affects VEGF-receptors (e.g.VEGFR3) through forward and reverse signalling pathways.The Ephrin-B2 path extends to lymphangiogenesis, leading to internalization of VEGFR3 in cultured lymphatic endothelial cells.