sentences:  Rat Cerebral cortex neurons and human neuroblastoma SH-SY5Y cells become apoptotic when treated with micromolar levels of 15-d-Δ12,14-PGJ2; this effect appears due to the ability of 15-d-Δ12,15-PGJ2 to inhibit the Phosphoinositide 3-kinase pathway of cell signaling.The direct injection of 15-d-Δ12,14-PGJ2 into the hippocampus proved to impair contextual memory retrieval in rats, again apparently acting by inhibiting the Phosphoinositide 3-kinase pathway.Based on these and other studies, the overproduction of cyclopentenone prostaglandins by the brain has been suggested to contribute to the neuron injury observed in various rodent models of neurodegenerative diseases and therefore may be relevant to the development and/or progression of the neuron injury occurring in human diseases such as Alzheimer's disease and Parkinson's disease.