sentences:  Clinically, the concern is that a single judicious amount of grapefruit ingested even many hours beforehand would noticeably boost oral drug bioavailability and cause overdose toxicity.Research findings have demonstrated that grapefruit produced a clinically relevant interaction with more than 40 medications.Formal product information for a number of highly prescribed or essential medications now warn about the risk of a grapefruit - induced adverse drug interaction.