sentences:  Methyl-MMDA-2 was first synthesized by Alexander Shulgin and was described in his book "PiHKAL".He states that it is essentially inactive at a dose of 70 mg, and he did not try any higher; however, Methyl-MMDA-2 is still likely to be active, perhaps in the 125-250 mg range.This reduction in hallucinogenic activity relative to MMDA-2 parallels that of MDA and MDMA, indicating that with phenethylamines, "N"-methylation substantially reduces 5-HT2A receptor affinity.