sentences:  It is unclear if this is a consequence of compensatory hyperdeiodination or if it results from impaired uptake by certain cell types.Increased T3 levels in the blood may be toxic to some organs and contribute to the signs and symptoms of Allan–Herndon–Dudley syndrome.In May 2013, the US FDA granted Orphan drug status to Diiodothyropropionic acid (DITPA) in the treatment of MCT8 deficiency.