sentences:  TLR5-deficient mice develop spontaneous colitis  and metabolic syndrome which are associated with altered gut microbiota.Statistically significant lower levels of TLR5 expression have been found in patients exhibiting moderate to severe ulcerative colitis (UC).In these patients, lower TLR5 mRNA levels were found along with decreased immunoreactivity of TLR5 in the inflamed mucosa of UC patients.