sentences:  Work with "Flcn"-deficient mouse models suggests a role for FLCN in regulating the AKT-mechanistic target of rapamycin (mTOR) signaling pathway, but the results are conflicting.mTOR activation was seen in the highly cystic kidneys that developed in mice with kidney-targeted inactivation of "Flcn".Elevated AKT and phospho-AKT proteins, and activation of mTORC1 and mTORC2 were observed in late-onset tumors that developed in aged "Flcn" heterozygous mice subsequent to loss of the remaining "Flcn" wild type allele, and in "FLCN"-deficient kidney tumors from BHD patients.