sentences:  FLCN expression was inversely correlated with PGC-1α activation, which drives mitochondrial biogenesis.In support of these data, FLCN inactivation was correlated with PGC-1α activation and upregulation of its target genes in BHD-associated renal tumors, and kidney, heart and muscle tissues from genetically engineered mouse models with " Flcn" inactivation targeted to the respective tissues.Yeast two-hybrid screening performed by two independent groups identified p0071 (plakophilin-4) as a FLCN interacting protein.