sentences:  Subsequently, cosegregation of kidney neoplasms with BHD cutaneous lesions was observed in 3 families with a family history of kidney tumors, suggesting that kidney tumors may be part of the BHD syndrome phenotype.In order to identify the genetic locus for BHD syndrome, genetic linkage analysis was performed in families recruited on the basis of BHD cutaneous lesions.A region spanning chromosome 17p11 was identified and mutations in a novel gene, "FLCN", were subsequently found in the germline of individuals affected with BHD syndrome.