sentences:  LKB1 in turn phosphorylates and activates AMPK, a negative regulator of mTOR activation.Flow stress was able to suppress mTOR signaling in FLCN-expressing human kidney cells but not under FLCN deficient conditions, and required intact cilia.FLCN was shown to recruit LKB1 and facilitate its interaction with AMPK in the basal body in a flow stress-dependent manner.