sentences:  On the other hand, mTOR inhibition was demonstrated in smaller cysts (although mTOR activation was seen in larger cysts) that developed in "Flcn" heterozygous knockout mice generated with a gene trapping approach.N-ethyl-N-nitrosourea (ENU) mutagenesis of another "Flcn" heterozygous mouse model produced tumors with reduced mTOR activity.Evidence from studies in yeast suggests that the FLCN ortholog Bhd activates the mTOR ortholog Tor2.