sentences:  Diagnosis requires conventional cytogenetics using Fluorescence in situ hybridization#Variations on probes and analysis with break-apart probes for "FGFR1".Unlike many other myeloid neoplasms with eosinophil such as those caused by Platelet-derived growth factor receptor A or platelet-derived growth factor receptor B fusion genes, the myelodysplasia syndromes caused by "FGFR"1 fusion genes in general do not respond to tyrosine kinase inhibitors, are aggressive and rapidly progressive, and require treatment with chemotherapy agents followed by bone marrow transplantion in order to improve survival.The tyrosine kinase inhibitor Ponatinib has been used as mono-therapy and subsequently used in combination with intensive chemotherapy to treat the myelodysplasia caused by the "FGFR1-BCR" fusion gene.