sentences:  The acid base pairs located in the middle of the interface are nearly parallel to each other, indicating a highly favorable interaction.The N-SH2 domain makes an additional polar contact through water-mediated interaction that takes place between the N-SH2 domain and the FGFR1 kinase region.The arginine residue 609 (R609) on the FGFR1 kinase also forms a salt bridge to the aspartate residue (D594) on the N-SH2 domain.