sentences:  Topical administration has been shown to have a degree of efficacy possibly through ultrastructural changes in platelets and platelet-constituent release.The effect of Yunnan Baiyao on the coagulation biochemical system has not been fully elucidated, but it has been suggested that the expression of glycoproteins on platlets plays a role.One "in vitro" study found that Yunnan Baiyao causes dose and time dependent hemangiosarcoma cell death through initiation of caspase-mediated cell apoptosis in a canine cell cancer line but did not suggest usefulness in patients.