sentences:  Embryos exhibit extensive deficiencies in the development and organization of mesoderm-derived tissues and the musculoskeletal system.The "Fgfr1" gene appears critical for the truncation of embryonic structures and formation of muscle and bone tissues and thereby the normal formation of limbs, skull, outer, middle, and inner ear, neural tube, tail, and lower spine as well as normal hearing.Hereditary mutations in the "FGFR1" gene are associated with various congenital malformations of the musculoskeletal system.