sentences:  A tyrosine-to-cysteine substitution mutation in the 372nd amino acid pf FGFR1 (Y372C) is responsible for some cases of Osteoglophonic dysplasia.This mutation results in craniosynostosis, mandibular prognathism, hypertelorism, brachydactyly, and inter-phalangeal joint fusion.Other inherited defects associated with "'FGFR1" mutations likewise involve musculoskeletal malformatios