sentences:  This lack of fragmentation typically hinders the acquisition of structural information, however thermospray is still capable of quantitative results and is valued for its range of viable analytes.When thermospray is coupled with High performance liquid chromatography mass spectrometry (TSP-HPLC-MS) the result is a highly sensitive method that is capable of lower detection limits than other HPLC-MS methods.Thermospray ionization has three possible processes by which it can occur.