sentences:  Unlike Protein A and Protein G, which bind to the Fc region of immunoglobulins (antibodies), Protein L binds antibodies through light chain interactions.Since no part of the heavy chain is involved in the binding interaction, Protein L binds a wider range of antibody classes than Protein A or G. Protein L binds to representatives of all antibody classes, including IgG, IgM, IgA, IgE and IgD.Single chain variable fragments (scFv) and Fab fragments also bind to Protein L.
  
  Despite this wide binding range, Protein L is not a universal antibody-binding protein.