sentences:  A fetus with 3C syndrome may have an umbilical cord with one umbilical artery instead of two.3C syndrome is an autosomal recessive disease, caused by a mutation on the long arm of chromosome 8 at 8q24.13, the locus for KIAA0196, the gene for the protein strumpellin.Strumpellin is highly expressed in skeletal muscle cells and mutations in it are also associated with spastic paraplegia.