sentences:  The surface-enhanced laser desorption/ionization (SELDI) variant is similar to MALDI, but uses a biochemical affinity target.The technique known as surface-enhanced neat desorption (SEND) is a related variant of MALDI with the matrix is covalently linked to the target surface.The SELDI technology was commercialized by Ciphergen Biosystems in 1997 as the ProteinChip system.