sentences:  Growth factors such as FGF2, HGF, EGF, VEGF, neuregulins and others interact with syndecans [1, 2, 8].For example, at the site of tissue injury, the soluble syndecan-1 ectodomains are cleaved by heparanases, producing heparin-like fragments that activate bFGF [13].Whereas most growth factors interact with syndecans via heparan sulfate chains, the prosecretory mitogen lacritin requires heparanase to both expose and create a binding site in the N-terminus of syndecan 1.