sentences:  Purine nucleoside phosphorylase deficiency
  
  Purine nucleoside phosphorylase deficiency, is a rare autosomal recessive metabolic disorder which results in immunodeficiency.In addition to the symptoms associated with immunodeficiency, such as depletion of T-cells, decline of lymphocyte activity, and an abrupt proliferation of both benign and opportunistic infections — PNP-deficiency is often characterized by the development of autoimmune disorders.