sentences:  Naturally occurring 4E-BPs are regulated by a protein kinase, mTOR, which through phosphorylation deactivates the binding affinity of 4E-BPs for the eIF4E protein.4EGI-1, like 4E-BP polypeptides, displaces eIF4G by associating with a binding site on eIF4E.Not only does the synthetic molecule prevent the association between the two initiation factors, but by binding to a different portion of eIF4E via the same motif, it has been shown to actually increase the binding affinity of eIF4E for "endogenous" (originating within an organism) 4E-BP1.