sentences:  Therapies such as the use of 4EGI-1 against cancer cells can thus be created such that their biologic targets include only the initiation factors involved in the production of weak mRNA’s.Cap-dependent translation involves a series of steps that join the small and large ribosomal subunits at the start codon of mRNA.The initiation factor complex eIF4F is dependent upon the presence of a 5’ mRNA cap upstream from the start codon in order to initiate translation.