sentences:  In parkinsonism, there is imbalance between levels of acetylcholine and dopamine in the brain, involving both increased levels of acetylcholine and degeneration of dopaminergic pathways (nigrostriatal pathway).Thus, in parkinsonism there is decreased level of dopaminergic activity.One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists.