sentences:  The enzyme catalyzes the transfer of a UDP-activator group from UDP-glucose to galactose-1-phosphate.Although the cause of enzyme deficiency in the Leloir pathway is still disputed amongst researchers, some studies suggest that protein misfolding of GALT, which may lead to an unfavorable conformational change that impacts its thermal stability and substrate-binding affinity, may play a role in the deficiency of GALT in Type 1 galactosemia.Increase in galactitol concentration can be seen in patients with galactosemia; putting patients at higher risk for presenile cataract.