sentences:  The modified forms of these proteins are involved in stimulation of gene expression via steroid hormone receptors.Significantly, PRMT4 methylates core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators.PRMT4 recruitment of chromatin by binding to coactivators increases histone methylation and enhances the accessibility of promoter regions for transcription.