sentences:  A few cases have shown rearrangement of the T-cell receptor β gene.Isochromosome 7q has been observed in all cases described so far, sometimes in conjunction with other chromosomal abnormalities such as trisomy 8.CHOP frequently induces remission initially, but has proven weak compared to treatments that integrate cytarabine with Hyper-CVAD being particularly effective, with chemo therapy only treatment most patients relapse and die within two years.