sentences:  It is believed he was in Rome around 1490.Even so, the actual formation of Macrino was obtained from his study of Tuscan and Umbrian masters such as Luca Signorelli and Perugino who worked at the papal seat.Macrino was an eminently eclectic painter and an extraordinary assimilator of aesthetic trends that had developed in Rome and Tuscany and had given birth to the Italian Renaissance.