sentences:  The fusion oncoprotein involves the gene AML1 (now known as RUNX1) and ETO (now known as RUNX1T1).AML1, located at the 21q22, normally has the ability to activate transcription of the ARF gene and ETO, located at the 8q22, normally has the ability to repress transcription.The fusion protein AML1-ETO is commonly found in acute myeloid leukemia patients.