sentences:  Doses are doubled, even tripled to treat severe pain, such as laminitis.The plasma (cytoplasm; the main part of the capsule) half-life of Tepoxalin is 4–8 hours, however the inflammatory entire metabolite (entirety of the capsule) half-life is 24 hours, so single dosing is more efficient for horses.When given at reasonable doses, the drug is non-toxic even when used repeatedly.