sentences:  The plasma concentration of Tepoxalin when administered varies between every dog, so there is no difference in administering between fed or fasted canines.However, there is a low water solubility and a high fat solubility, it is often prescribed to fed canines rather than fasted as this is more effective for Tepoxalin.In felines, Tepoxalin has an inhibitory action on COX-1 and 5-LOX enzymes in contrary in canines, Tepoxalin causes inhibition for COX-2 and 5-LOX enzymes.