sentences:  p14ARF is a well known tumor suppressor that serves as the safety net when p53 tumor suppressor's functions are inhibited.Many cancers recognize the potential of the p14ARF tumor suppressor to block cell growth so it is commonly mutated or inhibited in cancer cells.The AML1-ETO is incapable of p14ARF transcription as the fusion protein took on AML1's involvement with ARF gene expression and ETO's transcription repression.