sentences:  Chronic inflammatory diseases are the most common diseases in horses, phenylbutazone was used as an anti-inflammatory drug for horses, however when administered at high doses horses can develop ulcers of the glandular stomach, oral cavity and colon.Due to the major adverse effects of phenylbutazone, the replacement for Tepoxalin was made to be administered to horses to reduce muscular pain in 2003.In horses, the drug is intravenously administered at 10 mg/kg on a daily dose for 10 days respectively.