sentences:  This is similar to the effects of choline-stabilized orthosilicic acid.Strontium ranelate stimulates the calcium-sensing receptors and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.Strontium ranelate also stimulates osteoblasts to secrete osteoprotegerin in inhibiting osteoclasts formed from pre-osteoclasts in relation to the RANKL system, which leads to the decrease of bone resorption.