sentences:  This inflammatory cascade typically leads to the formation of inflammatory acne lesions, including papules, infected pustules, or nodules.If the inflammatory reaction is severe, the follicle can break into the deeper layers of the dermis and subcutaneous tissue and cause the formation of deep nodules.The involvement of AP-1 in the aforementioned inflammatory cascade activates matrix metalloproteinases, which contribute to local tissue destruction and scar formation.