sentences:  Activation of TLR2 and TLR4 by "C. acnes" leads to increased secretion of IL-1α, IL-8, and TNF-α.The release of these inflammatory signals attracts various immune cells to the hair follicle, including neutrophils, macrophages, and Th1 cells.IL-1α stimulates increased skin cell activity and reproduction, which, in turn, fuels comedo development.