sentences:  The medication appears to be effective in the treatment of acne in males, with one study finding that a high dosage reduced inflammatory acne lesions by 73%.However, spironolactone and cyproterone acetate's side effects in males, such as gynecomastia, sexual dysfunction, and decreased bone mineral density, make its use for male acne impractical in most cases.Pregnant and lactating women should not receive hormonal therapies for their acne due to an association with birth disorders such as hypospadias, and the feminization of male babies.