sentences:  Bicalutamide, a pure androgen receptor antagonist with the same mechanism as flutamide and with comparable or superior antiandrogenic efficacy but without its risk of liver toxicity, is a potential alternative to flutamide in the treatment of androgen-dependent skin and hair conditions in women.Clascoterone is a topical antiandrogen that has demonstrated effectiveness in the treatment of acne in both males and females and is currently in the late stages of clinical development.It has shown no systemic absorption or associated antiandrogenic side effects.