sentences:  Oral antibiotics remain the most commonly prescribed systemic therapy for acne.Widespread broad-spectrum antibiotic overuse for acne has led to higher rates of antibiotic-resistant "C. acnes" strains worldwide, especially to the commonly used tetracycline (e.g., doxycycline) and macrolide antibiotics (e.g., topical erythromycin).Therefore, dermatologists prefer antibiotics as part of combination therapy and not for use alone.