sentences:  Acne susceptibility is likely due to the influence of multiple genes, as the disease does not follow a classic (Mendelian) inheritance pattern.These gene candidates include certain variations in tumor necrosis factor-alpha (TNF-alpha), IL-1 alpha, and CYP1A1 genes, among others.The 308 G/A single nucleotide polymorphism variation in the gene for TNF is associated with an increased risk for acne.