sentences:  The two domains are separated by a deep groove that contains the maltose/maltodextrins binding site.Comparison of the structures of the liganded and unliganded forms of MBP has shown that the binding of maltose induces a major conformational change that closes the groove by a rigid motion of the two domains around the linking polypeptide hinge.Both precursor and mature forms of MBP are functional for the binding of maltose.