sentences:  Fz produces an mRNA that encodes an integral membrane protein with 7 putative transmembrane (TM) domains.This protein should contain both extracellular and cytoplasmic domains, which could function in the transmission and interpretation of polarity information.This signature is usually found downstream of the Fz domain ()
  
  Frizzled proteins include cysteine-rich domain that is conserved in diverse proteins, including several receptor tyrosine kinases.