sentences:  ATR is also linked to familial cutaneous telangiectasia and cancer syndrome.ATR/ChK1 inhibitors can potentiate the effect of DNA cross-linking agents.The first clinical trials using inhibitors of ATR have been initiated by AstraZeneca, preferably in ATM-mutated chronic lymphocytic leukaemia (CLL), prolymphocytic leukaemia (PLL) or B-cell lymphoma patients and by Vertex Pharmaceuticals in advanced solid tumours.