sentences:  This drug was discovered by Cambridge Antibody Technology, now AstraZeneca, and Human Genome Sciences, now GlaxoSmithKline, as a result of the collaboration between the two companies in 1999 in exploitation of CAT's phage display technology.Early work by the two companies indicated that mapatumumab induced cell death in multiple tumor types both in vitro and in vivo.A phase 1 clinical trial in 2004 demonstrated the safety and tolerability of mapatumumab in cancer patients with advanced solid tumors or non-Hodgkin’s lymphoma, and supported further evaluation in phase 2 clinical trials, both as a single agent and in combination with chemotherapy.