sentences:  TGFβ signaling at the cell membrane results in 2 different intracellular pathways.One of them depends on MED15, while the other is independent of MED15.In both human cells and "Caenorhabditis elegans" MED15 is involved in lipid homeostasis through the pathway involving SREBPs In the model plant "Arabidopsis thaliana" the ortholog of MED15 is required for signaling by a plant hormone.