sentences:  Sld3, Sld2, and Dpb11 interact with many replication proteins.Sld3 and Cdc45 form a complex that associated with the pre-RC at the early origins of replication even in the G11 phase and with the later origins of replication in the S phase in a mutually Mcm-dependent manner.Dpb11 and Sld2 interact with Polymerase ɛ and cross-linking experiments have indicated that Dpb11 and Polymerase ɛ coprecipitate in the S phase and associate with replication origins.