sentences:  These studies, confirmed by cryo-EM structures of the Mcm2-7 complexes, suggest that the Mcm complex is a hexamer with Mcm3 next to Mcm7, Mcm2 next to Mcm6, and Mcm4 next to Mcm5.Both members of the catalytic pair contribute to the conformation that allows ATP binding and hydrolysis and the mixture of active and inactive subunits create a coordinated ATPase activity that allows the Mcm protein complex to complete ATP binding and hydrolysis as a whole.The nuclear localization of the minichromosome maintenance proteins is regulated in budding yeast cells.