sentences:  This clockwise and counter-clockwise movement of two replicons is termed as bidirectional replication.Eukaryotic DNA replication requires precise coordination of all DNA polymerases and associated proteins to replicate the entire genome each time a cell divides.This process is achieved through a series of steps of protein assemblies at origins of replication, mainly focusing the regulation of DNA replication on the association of the MCM helicase with the DNA.