sentences:  Another histone chaperone that associates with the replisome is Asf1, which interacts with the Mcm complex dependent on histone dimers H3-H4.Asf1 is able to pass newly synthesized H3-H4 dimer to deposition factors behind the replication fork and this activity makes the H3-H4 histone dimers available at the site of histone deposition just after replication.Asf1 (and its partner Rtt109) has also been implicated in inhibiting gene expression from replicated genes during S-phase.