sentences:  Cdc45, Mcm2-7 and GINS together form the CMG helicase,, the replicative helicase of the replisome.Although the Mcm2-7 complex alone has weak helicase activity  Cdc45 and GINS are required for robust helicase activity
  
  Mcm10 is essential for chromosome replication and interacts with the minichromosome maintenance 2-7 helicase that is loaded in an inactive form at origins of DNA replication.Mcm10 also chaperones the catalytic DNA polymerase α and helps stabilize the polymerase at replication forks.