sentences:  Ctf4/And1 proteins interact with both the CMG complex and DNA polymerase α. Ctf4 is a polymerase α accessory factor, which is required for the recruitment of polymerase α to replication origins.Mrc1/Claspin proteins couple leading-strand synthesis with the CMG complex helicase activity.Mrc1 interacts with polymerase ε as well as Mcm proteins.