sentences:  The Chk1-dependent Cdk inhibition is important for the function of the ATR-Chk1 checkpoint and to arrest the cell cycle and allow sufficient time for completion of DNA repair mechanisms, which in turn prevents the inheritance of damaged DNA.In addition, Chk1-dependent Cdk inhibition plays a critical role in inhibiting origin firing during S phase.This mechanism prevents continued DNA synthesis and is required for the protection of the genome in the
  presence of replication stress and potential genotoxic conditions.