sentences:  Generally, the function and size of the ORC subunits are conserved throughout many eukaryotic genomes with the difference being their diverged DNA binding sites.The most widely studied origin recognition complex is that of "Saccharomyces cerevisiae" or yeast which is known to bind to the autonomously replicating sequence (ARS).The "S. cerevisiae" ORC interacts specifically with both the A and B1 elements of yeast origins of replication, spanning a region of 30 base pairs.