sentences:  DnaA-ATP is hydrolyzed into the inactive DnaA-ADP by RIDA (Regulatory Inactivation of DnaA), and converted back to the active DnaA-ATP form by DARS (DnaA Reactivating Sequence, which is itself regulated by Fis and IHF).However, the main source of DnaA-ATP is synthesis of new molecules.Meanwhile, several other proteins interact directly with the "oriC" sequence to regulate initiation, usually by inhibition.