sentences:  In late mitosis, Cdc6 protein joins the bound ORC followed by the binding of the Cdt1-Mcm2-7 complex.ORC, Cdc6, and Cdt1 are all required to load the six protein minichromosome maintenance (Mcm 2-7) complex onto the DNA.The ORC is a six-subunit, Orc1p-6, protein complex that selects the replicative origin sites on DNA for initiation of replication and ORC binding to chromatin is regulated through the cell cycle.