sentences:  The ARS DNA is also bent at the B1 element through interactions with Orc2, Orc5 and Orc6.The bending of origin DNA by ORC appears to be evolutionarily conserved suggesting that it may be required for the Mcm2-7 complex loading mechanism.When the ORC binds to DNA at replication origins, it serves as a scaffold for the assembly of other key initiation factors of the pre-replicative complex.