sentences:  Type I IFNs bind to IFNAR1 or IFNAR2, forming a binary complex.The binary complex further recruits the remaining IFNAR subunit, completing the ternary complex and activating downstream JAK/STAT signaling.IFN ligation to IFNAR brings the receptor associated kinases, JAK1 and Tyk2, into close proximity, resulting in kinase transphosphorylation and subsequent phosphorylation of tyrosines on IFNAR1 and IFNAR2.