sentences:  There were, however, mutations in four other genes in ALL patients that destabilized the MSH2 protein, and these were defective in 11% of children with ALL and 16% of adults with this cancer.Methylation of the promoter region of the "MSH2" gene is correlated with the lack of expression of the MSH2 protein in esophageal cancer, in non-small-cell lung cancer, and in colorectal cancer.These correlations suggest that methylation of the promoter region of the "MSH2" gene reduces expression of the MSH2 protein.