sentences:  Orthologs of human MLH1 have also been studied in other organisms including mouse and the budding yeast "Saccharomyces cerevisiae".This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer.It is a human homolog of the "E. coli" DNA mismatch repair gene, mutL, which mediates protein-protein interactions during mismatch recognition, strand discrimination, and strand removal.