sentences:  IFNAR agonism results in transcriptional changes, with the potential to increase or suppress the transcription of over 2000 different genes.For example, type I IFNs induce interferon-stimulated gene (ISG) expression, classically resulting in a robust anti-viral immune response.Additionally, IFNs largely impact cell health and viability, with effects on apoptosis, autophagy, cell differentiation, and proliferation.