sentences:  Conversely, increased expression of STAT1 and IRF9 maintain ISG expression, even in the absence of on-going cytokine receptor signaling, thereby amplifying IFNAR signaling.Because type I IFN signaling modulates proteins involved in protein translation, it can also indirectly alter protein levels of induced genes and proteins involved in pathway signaling.Type I IFN subtypes, ranging from 30–70% homology, all bind the same receptor.