sentences:  Electron microscopy experiments show IFNAR receptors concentrated in clathrin-coated pits, and inhibition of clathrin-mediated endocytosis resulted in reduced phosphorylation of JAK1, Tyk2, STATs and reduced STAT nuclear translocation.Negative regulators of type I IFN signaling, such as suppressor of cytokine signaling 1 (SOCS1) and ubiquitin-specific peptidase 18 (USP18), are induced after 4 hours.SOCS1 inhibits type I IFN signaling by inhibiting JAKs and binding phosphorylated Tyk2.