sentences:  However, responsiveness to IFNα is ablated, likely due to the reduced IFNAR1 membrane expression.IFNAR1 binding to low affinity ligands, such as IFNα subtypes, has been proposed to be the rate limiting step in the ternary complex formation.Therefore, if membrane levels of IFNAR1 are too low, the binary IFNα-IFNAR2 complex will be unable to recruit it to induce signaling.