sentences:  The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair.Defects in hMSH6 are associated with atypical hereditary nonpolyposis colorectal cancer not fulfilling the Amsterdam criteria for HNPCC.hMSH6 mutations have also been linked to endometrial cancer and the development of endometrial carcinomas.