sentences:  For example, membrane IFNAR1 is reduced in response to IFNα, but surface levels IFNAR1 and IFNAR2 are downregulated in response to IFNβ binding.In agreement with these observations, IFNAR internalization is often associated with the respective agonist's ability to induce an anti-proliferative effect.IFNAR subunit internalization is also observed under basal conditions, with greater basal turnover of IFNAR1 than IFNAR2.