sentences:  IFNAR surface expression is maintained in the presence of stimulation when the clathrin-dependent endocytosis pathway is inhibited with siRNA knockdown of clathrin or using a small molecule inhibitor of the GTPase dynamin.Internalization can result in degradation of the receptor, thereby reducing membrane expression, or it can result in recycling of the receptor without an extended impact on membrane receptor levels.However, clathrin-mediated endocytosis may also serve to concentrate the IFNAR receptors and signaling components, thereby amplifying signaling.