sentences:  Furthermore, while differential effects manifest after several days of chronic stimulation, changes to receptor structure, orientation, or stoichiometry have not elucidated the cause for differential signaling via different type I IFN subtypes.Current hypotheses for differential signaling include ligand-specific differences to the stability, or lifetime, of the ternary complex, ligand-induced changes to internalization and trafficking of the receptor and currently unappreciated differences to ligand-receptor structure.Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand.