sentences:  Type I IFN is also being investigated for a potential role in neurodegeneration; loss of IFNAR expression prolonged survival in murine models of amyotrophic lateral sclerosis (ALS).IFNα has also been used in the clinic for the treatment of type I IFN responsive hematological malignancies, such as chronic myelogenous leukemia (CML), multiple myeloma, and hairy cell leukemia.Importantly, type I IFN-resistant cancers have been shown to have low or absent IFNAR expression.