sentences:  The onset of endometrial cancer and also colon cancer in families with hMSH6 mutations is about 50 years.This is delayed compared to the age 44 onset of hMSH2-related tumors.Two microRNAs, miR21 and miR-155, target the DNA mismatch repair (MMR) genes "hMSH6" and "hMSH2", to cause reduced expression of their proteins.