sentences:  CHS contains a five layer αβαβα core, a location of the active site and dimerization interface that is highly similar to thiolase-fold containing enzymes.The dimerization interface contains both hydrophobic and hydrophilic residues and is generally flat except for a pair of N-terminal helices that lay entwined across the top.Although the helices are not involved in reaction, they may contain intracellular localization signals as in yeast thiolase.