sentences:  Oligonucleotides, DNA, or RNA will bind to their complement under normal conditions, so two perfectly complementary strands will bind to each other readily.In order to reduce the diversity and obtain the most energetically preferred complexes, a technique called annealing is used in laboratory practice.However, due to the different molecular geometries of the nucleotides, a single inconsistency between the two strands will make binding between them less energetically favorable.